FHL5 and CREM

Number of citations of the paper that reports this interaction (PubMedID 10086359)
43

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FHL5	CREM
Description		four and a half LIM domains 5	cAMP responsive element modulator
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Z Disc	Nuclear Chromatin Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding CAMP Response Element Binding Protein Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Glucose Metabolic Process Regulation Of Transcription, DNA-templated Fatty Acid Metabolic Process Glycosphingolipid Metabolic Process Signal Transduction Multicellular Organism Development Spermatogenesis Cell Differentiation Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Rhythmic Process
Pathways
Drugs
Diseases
GWAS		Cerebral blood flow ( 28627999) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Headache ( 29397368) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418) Spatial memory ( 31596458)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diarrhoea-associated Entamoeba histolytica infection ( 30228239) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		13 interacting genes: BANP COIL CREB1 CREM CRYBA4 DNAL4 FAM214B FHL2 KIF17 SMAD1 SRF ZNF446 ZNF688	30 interacting genes: ATF1 ATXN1 CAMK2D CAMK2G CASP8AP2 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 CUL2 DNMT3L EMP3 FHL5 GSK3A GSK3B HDAC1 KCNIP3 MAPK3 PIAS3 PRKACA PRKCA SP100 SPI1 TAF4 TBP UBE2I
Entrez ID		9457	1390
HPRD ID		05497	00444
Ensembl ID		ENSG00000112214	ENSG00000095794
Uniprot IDs		Q5TD97	Q03060
PDB IDs		1X68
Enriched GO Terms of Interacting Partners?
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