CREM and CREB3L1

Number of citations of the paper that reports this interaction (PubMedID 12805554)
150

Data Source:
HPRD (in vitro)

		CREM	CREB3L1
Description		cAMP responsive element modulator	cAMP responsive element binding protein 3 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Cytoplasm	Nuclear Chromatin Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding CAMP Response Element Binding Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding CAMP Response Element Binding Transcription Regulatory Region DNA Binding SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glucose Metabolic Process Regulation Of Transcription, DNA-templated Fatty Acid Metabolic Process Glycosphingolipid Metabolic Process Signal Transduction Multicellular Organism Development Spermatogenesis Cell Differentiation Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Rhythmic Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Multicellular Organism Development Negative Regulation Of Gene Expression Viral Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Extracellular Matrix Constituent Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways			CREB3 factors activate genes
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diarrhoea-associated Entamoeba histolytica infection ( 30228239) Inflammatory bowel disease ( 28067908 23128233)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Fasting blood glucose ( 22581228) LDL cholesterol ( 30275531) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Schizophrenia ( 29483656) Systolic blood pressure ( 30578418)
Interacting Genes		30 interacting genes: ATF1 ATXN1 CAMK2D CAMK2G CASP8AP2 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 CUL2 DNMT3L EMP3 FHL5 GSK3A GSK3B HDAC1 KCNIP3 MAPK3 PIAS3 PRKACA PRKCA SP100 SPI1 TAF4 TBP UBE2I	30 interacting genes: C5 CD99L2 CFHR5 CREB3 CREB3L3 CREM CYBC1 DDIT3 FAM3C FXYD3 FXYD6 GPR25 HIF1A JAGN1 MFSD5 NRM PGAP2 PGRMC1 PLN PLP1 PRKAB2 RUNX1T1 SLC30A8 SLC35B4 TMEM11 TMEM128 TMEM147 TMEM218 TMEM234 TSPO
Entrez ID		1390	90993
HPRD ID		00444	16751
Ensembl ID		ENSG00000095794	ENSG00000157613
Uniprot IDs		Q03060	B2RA75 Q96BA8
PDB IDs
Enriched GO Terms of Interacting Partners?
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