CREM and FHL5

Number of citations of the paper that reports this interaction (PubMedID 10086359)
43

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CREM	FHL5
Description		cAMP responsive element modulator	four and a half LIM domains 5
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Transcription Factor Complex Cytoplasm	Nucleus Z Disc
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding CAMP Response Element Binding Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glucose Metabolic Process Regulation Of Transcription, DNA-templated Fatty Acid Metabolic Process Glycosphingolipid Metabolic Process Signal Transduction Multicellular Organism Development Spermatogenesis Cell Differentiation Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Rhythmic Process	Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diarrhoea-associated Entamoeba histolytica infection ( 30228239) Inflammatory bowel disease ( 28067908 23128233)	Cerebral blood flow ( 28627999) Coronary artery disease ( 29212778) Coronary heart disease ( 22319020) Headache ( 29397368) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 30578418) Spatial memory ( 31596458)
Interacting Genes		30 interacting genes: ATF1 ATXN1 CAMK2D CAMK2G CASP8AP2 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 CUL2 DNMT3L EMP3 FHL5 GSK3A GSK3B HDAC1 KCNIP3 MAPK3 PIAS3 PRKACA PRKCA SP100 SPI1 TAF4 TBP UBE2I	13 interacting genes: BANP COIL CREB1 CREM CRYBA4 DNAL4 FAM214B FHL2 KIF17 SMAD1 SRF ZNF446 ZNF688
Entrez ID		1390	9457
HPRD ID		00444	05497
Ensembl ID		ENSG00000095794	ENSG00000112214
Uniprot IDs		Q03060	Q5TD97
PDB IDs			1X68
Enriched GO Terms of Interacting Partners?
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