HOMER1 and GRM5

Number of citations of the paper that reports this interaction (PubMedID 9069287)
283

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		HOMER1	GRM5
Description		homer scaffold protein 1	glutamate metabotropic receptor 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Z Disc Cell Junction Axon Dendrite Neuron Projection Costamere Dendritic Spine Neuron Spine Apical Part Of Cell Glutamatergic Synapse Postsynaptic Cytosol	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane
	Molecular Function	Protein Binding G Protein-coupled Glutamate Receptor Binding Signaling Adaptor Activity Ion Channel Binding	G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity Protein Tyrosine Kinase Activator Activity Identical Protein Binding G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Protein Tyrosine Kinase Binding
	Biological Process	Skeletal Muscle Contraction Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Behavioral Response To Cocaine Skeletal Muscle Fiber Development Chemical Homeostasis Within A Tissue Protein Tetramerization Response To Calcium Ion Positive Regulation Of Calcium Ion Transport Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Calcium Ion Import Regulation Of Postsynaptic Neurotransmitter Receptor Activity Regulation Of Dendritic Spine Maintenance Regulation Of Store-operated Calcium Entry Regulation Of Cation Channel Activity	Regulation Of Protein Phosphorylation Regulation Of Translation Regulation Of Translational Elongation G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Learning Locomotory Behavior Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Long-term Neuronal Synaptic Plasticity Synapse Organization Cognition Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Protein Tyrosine Kinase Activity Modulation Of Age-related Behavioral Decline Postsynaptic Modulation Of Chemical Synaptic Transmission Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Intracellular Calcium Activated Chloride Channel Activity Cellular Response To Amyloid-beta
Pathways		Neurexins and neuroligins Neurexins and neuroligins	G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins
Drugs			Acamprosate ADX10059 Rufinamide Dipraglurant
Diseases
GWAS		Bipolar disorder ( 31043756) Blood and toenail selenium levels ( 25343990) Height ( 18193045) Hepcidin/ferritin ratio ( 27846281) Lateral ventricle temporal horn volume ( 31530798) Major depressive disorder ( 20673876) Metabolite levels ( 23823483) Toenail selenium levels ( 25343990)	Attention deficit hyperactivity disorder ( 22012869) Blond vs. brown/black hair color ( 30531825) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) General factor of neuroticism ( 30867560) Hair color ( 30664655) Hypertension ( 31879980) Neurociticism ( 29500382) Nonsyndromic cleft lip ( 31609978) Rheumatoid arthritis (ACPA-negative) ( 24532677) Skin pigmentation ( 31315583 30664655) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Tanning ( 19340012)
Interacting Genes		20 interacting genes: ABI3 AGAP2 C19orf57 C1orf116 DBNL DNM3 EFNB2 FAT1 GRIA1 GRIK1 GRM1 GRM5 HOMER3 ITPR1 RYR1 RYR2 SHANK1 STX12 TANC1 TRPC1	19 interacting genes: ACTN1 CALM1 CALM2 CALM3 EFNB2 FLNA GPRASP1 HOMER1 HOMER3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ RGS12 SIAH1 TAMALIN
Entrez ID		9456	2915
HPRD ID		09211	04980
Ensembl ID		ENSG00000152413	ENSG00000168959
Uniprot IDs		Q5U5K4 Q86YM7	A8K5P7 P41594
PDB IDs			3LMK 4OO9 5CGC 5CGD 6N4X 6N4Y 6N50 6N51 6N52
Enriched GO Terms of Interacting Partners?
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