MED17 and SUZ12

Number of citations of the paper that reports this interaction (PubMedID 22668559)
6

Data Source:
BioGRID (pull down)

		MED17	SUZ12
Description		mediator complex subunit 17	SUZ12 polycomb repressive complex 2 subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Membrane Mediator Complex Core Mediator Complex	Sex Chromatin Nucleus Nucleoplasm Nucleolus RSC-type Complex Nuclear Body Protein-DNA Complex ESC/E(Z) Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K27 Specific) Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Histone Ubiquitination Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Oligodendrocyte Differentiation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs
Diseases
GWAS			High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		16 interacting genes: BCL6 CTDP1 ESR1 ESR2 HEMGN HNF4A MED19 MED22 MED30 MED8 PPARGC1A SMARCA4 SREBF1 SUZ12 TP53 USP49	17 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 CTCF EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 UBE2I WDR77
Entrez ID		9440	23512
HPRD ID		04816	06949
Ensembl ID		ENSG00000042429	ENSG00000178691
Uniprot IDs		Q9NVC6	J3QQW9 Q15022
PDB IDs			4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24
Enriched GO Terms of Interacting Partners?
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