SUZ12 and BCL11A

Number of citations of the paper that reports this interaction (PubMedID 29263092)
9

Data Source:
BioGRID (pull down)

		SUZ12	BCL11A
Description		SUZ12 polycomb repressive complex 2 subunit	BAF chromatin remodeling complex subunit BCL11A
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GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nucleolus RSC-type Complex Nuclear Body Protein-DNA Complex ESC/E(Z) Complex	Nucleus Nucleoplasm Cytoplasm Postsynaptic Density
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K27 Specific) Promoter-specific Chromatin Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Kinase Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Histone Ubiquitination Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Oligodendrocyte Differentiation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Multicellular Organism Development Positive Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Dendrite Extension Negative Regulation Of Neuron Remodeling Cellular Response To L-glutamate Negative Regulation Of Dendrite Development Negative Regulation Of Branching Morphogenesis Of A Nerve
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs
Diseases
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)	Acne (severe) ( 24927181 30542056) Attention deficit hyperactivity disorder ( 22012869) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Beta thalassemia/hemoglobin E disease ( 20183929) Childhood absence epilepsy ( 30531953) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epilepsy ( 30531953) F-cell distribution ( 17767159) F-cell distribution in sickle cell anaemia ( 21326311) Face memory ( 31596458) Fetal hemoglobin levels ( 18245381 20018918) Fetal hemoglobin levels in sickle cell anemia ( 25372704) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Generalized epilepsy ( 30531953) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heel bone mineral density ( 30598549) Hemoglobin A2 levels in sickle cell anemia ( 25042611) Hemoglobin levels ( 26366553) High fetal hemoglobin in sickle cell disease ( 27022141) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Hypersomnia (HLA-DQB1*06:02 negative) ( 23646285) Immature fraction of reticulocytes ( 27863252) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252 28017375 19862010) Menarche (age at onset) ( 25231870) Methadone dose in opioid dependence ( 28115739) Monocyte early outgrowth colony forming units ( 21493818) Morning person ( 30696823) Number of sexual partners ( 30643258) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Prostate-specific antigen levels ( 30410027 28139693) Red blood cell count ( 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Resting heart rate ( 27798624) Risk-taking tendency (4-domain principal component model) ( 30643258) Sickle cell anemia (haemolysis) ( 23406172) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Type 2 diabetes ( 22885922 24509480 29358691 30297969 20581827 30718926 28869590) Urinary albumin-to-creatinine ratio in diabetes ( 31511532)
Interacting Genes		17 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 CTCF EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 UBE2I WDR77	26 interacting genes: ACTC1 APP BCL6 CDCA3 CDK4 CDK6 EZH2 GMCL2 HDAC1 HDAC2 LMO1 MTA1 NCK2 NR2E1 NR2E3 NR2F1 NR2F2 NR2F6 RBBP4 RBBP7 SIN3A SIRT1 SUZ12 UBE2I YME1L1 ZBTB24
Entrez ID		23512	53335
HPRD ID		06949	05949
Ensembl ID		ENSG00000178691	ENSG00000119866
Uniprot IDs		J3QQW9 Q15022	D9YZV9 D9YZW0 Q9H165
PDB IDs		4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24	5VTB 6KI6
Enriched GO Terms of Interacting Partners?
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