SUZ12 and MED6

Number of citations of the paper that reports this interaction (PubMedID 22668559)
6

Data Source:
BioGRID (pull down)

		SUZ12	MED6
Description		SUZ12 polycomb repressive complex 2 subunit	mediator complex subunit 6
Image			No pdb structure
GO Annotations	Cellular Component	Sex Chromatin Nucleus Nucleoplasm Nucleolus RSC-type Complex Nuclear Body Protein-DNA Complex ESC/E(Z) Complex	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K27 Specific) Promoter-specific Chromatin Binding	Transcription Coactivator Activity Protein Binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Histone Ubiquitination Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Oligodendrocyte Differentiation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly
Pathways		PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		17 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 CTCF EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 UBE2I WDR77	15 interacting genes: BCL6 CTDP1 ESR1 ESR2 MED25 MED8 MED9 PARP1 RARA SMAD1 SMAD2 SMARCA4 SREBF1 SUZ12 TARDBP
Entrez ID		23512	10001
HPRD ID		06949	04284
Ensembl ID		ENSG00000178691	ENSG00000133997
Uniprot IDs		J3QQW9 Q15022	A0A087WYL7 O75586
PDB IDs		4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24
Enriched GO Terms of Interacting Partners?
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