LHX2 and LDB1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		LHX2	LDB1
Description		LIM homeobox 2	LIM domain binding 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cell Leading Edge Protein-containing Complex Beta-catenin-TCF Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Transcription Factor Binding Metal Ion Binding	RNA Polymerase II Activating Transcription Factor Binding Transcription Corepressor Activity Protein Binding Enzyme Binding LIM Domain Binding Protein Homodimerization Activity
	Biological Process	Neural Tube Closure Hair Follicle Development Axon Guidance Mesoderm Development Dorsal/ventral Pattern Formation Olfactory Bulb Development Telencephalon Regionalization Cerebral Cortex Development Neuron Differentiation Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Axon Extension Negative Regulation Of Neurogenesis Retina Development In Camera-type Eye Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Transcription Regulatory Region DNA Binding	Negative Regulation Of Transcription By RNA Polymerase II Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organism Development Neuron Differentiation Regulation Of Cell Migration Regulation Of DNA-templated Transcription, Elongation Regulation Of Kinase Activity Histone H3-K4 Acetylation Negative Regulation Of Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Regulation Of Focal Adhesion Assembly Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Regulation of expression of SLITs and ROBOs	RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Blond vs. brown/black hair color ( 30531825) Depression ( 29700475) Hair color ( 29662168) Mercury levels ( 26025379) Post-traumatic stress disorder ( 25456346) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Waist circumference ( 23966867)	General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Pulse pressure ( 30578418)
Interacting Genes		6 interacting genes: CITED2 DNMT3L LDB1 MSX1 PAX6 RLIM	27 interacting genes: ATXN1 CTDSP1 DNMT3L ESR1 IRAK3 ISL1 LHX2 LHX3 LHX8 LMO1 LMO2 LMO3 LMO4 LMX1A LMX1B LSM7 POLR1B PSMA1 PSMD10 RLIM SP1 SSBP1 SSBP2 SSBP3 SSBP4 TOLLIP UPF1
Entrez ID		9355	8861
HPRD ID		04786	09144
Ensembl ID		ENSG00000106689	ENSG00000198728
Uniprot IDs		B3KNJ5 P50458	Q86U70
PDB IDs			2XJY 2XJZ 2YPA
Enriched GO Terms of Interacting Partners?
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