NOLC1 and E2F4

Number of citations of the paper that reports this interaction (PubMedID 8657117)
113

Data Source:
HPRD (in vivo, in vitro)

		NOLC1	E2F4
Description		nucleolar and coiled-body phosphoprotein 1	E2F transcription factor 4
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Cajal Body Box C/D SnoRNP Complex Box H/ACA SnoRNP Complex	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase I Core Binding DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding ATP Binding GTP Binding Transcription Factor Binding Nuclear Localization Sequence Binding Protein Domain Specific Binding Box C/D SnoRNA Binding Box H/ACA SnoRNA Binding Protein Heterodimerization Activity Box C/D SnoRNP Complex Binding Box H/ACA SnoRNP Complex Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Bacterial-type RNA Polymerase Transcriptional Activator Activity, Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Sequence-specific DNA Binding Protein Dimerization Activity Promoter-specific Chromatin Binding
	Biological Process	Mitotic Cell Cycle RRNA Processing Regulation Of Translation Response To Osmotic Stress Nucleolus Organization Positive Regulation Of Cell Proliferation Neural Crest Formation Neural Crest Cell Development Box H/ACA SnoRNA Metabolic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Epithelial Cell Development Cell Volume Homeostasis DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Blood Circulation Animal Organ Morphogenesis Regulation Of Cell Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways			Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs		Doxorubicin
Diseases
GWAS
Interacting Genes		16 interacting genes: APP CEBPB COIL CSNK2A1 CSNK2B E2F4 ERG GTF2B KBTBD8 MDM2 POLR1A PRKACA SRPK2 USP4 YWHAG YWHAQ	29 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK FHL2 HCFC1 ID3 IKBKB LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1
Entrez ID		9221	1874
HPRD ID		03864	02806
Ensembl ID		ENSG00000166197	ENSG00000205250
Uniprot IDs		B2RAU8 Q14978 Q96J17	Q16254
PDB IDs			1CF7 5TUU
Enriched GO Terms of Interacting Partners?
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