E2F4 and ARID3A

Number of citations of the paper that reports this interaction (PubMedID 15017387)
9

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		E2F4	ARID3A
Description		E2F transcription factor 4	AT-rich interaction domain 3A
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GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm Cytosol Membrane Raft
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Bacterial-type RNA Polymerase Transcriptional Activator Activity, Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Sequence-specific DNA Binding Protein Dimerization Activity Promoter-specific Chromatin Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Epithelial Cell Development Cell Volume Homeostasis DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Blood Circulation Animal Organ Morphogenesis Regulation Of Cell Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Centriole Assembly Multi-ciliated Epithelial Cell Differentiation	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Drugs
Diseases
GWAS			Immature fraction of reticulocytes ( 27863252) Primary biliary cholangitis ( 28425483) Systemic lupus erythematosus ( 28714469) Vertical cup-disc ratio ( 20548946)
Interacting Genes		29 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK FHL2 HCFC1 ID3 IKBKB LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1	12 interacting genes: APP BTK DSP E2F1 E2F2 E2F4 NOTCH2NLA PML SP100 TP53 TTC32 UBE2E3
Entrez ID		1874	1820
HPRD ID		02806	10343
Ensembl ID		ENSG00000205250	ENSG00000116017
Uniprot IDs		Q16254	Q99856
PDB IDs		1CF7 5TUU	2KK0 4LJX
Enriched GO Terms of Interacting Partners?
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