SGPL1 and STING1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
114

Data Source:
BioGRID (pull down)

		SGPL1	STING1
Description		sphingosine-1-phosphate lyase 1	stimulator of interferon response cGAMP interactor 1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane	Autophagosome Membrane Nucleoplasm Mitochondrial Outer Membrane Endosome Autophagosome Peroxisome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Cytoplasmic Vesicle Membrane Secretory Granule Membrane Perinuclear Region Of Cytoplasm Integral Component Of Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
	Molecular Function	Protein Binding Sphinganine-1-phosphate Aldolase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding	Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Cyclic-di-GMP Binding Identical Protein Binding Protein Homodimerization Activity Cyclic-GMP-AMP Binding
	Biological Process	Luteinization Vasculogenesis Ameboidal-type Cell Migration Kidney Development Fatty Acid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Fibroblast Migration Hemopoiesis Sphingolipid Biosynthetic Process Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway	Autophagosome Assembly Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Viral Process Positive Regulation Of Macroautophagy Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Interferon-beta Production Cellular Response To Interferon-beta Neutrophil Degranulation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Positive Regulation Of DNA-binding Transcription Factor Activity Protein Complex Oligomerization Defense Response To Virus Reticulophagy Cellular Response To Exogenous DsRNA Cellular Response To Organic Cyclic Compound
Pathways		Sphingolipid de novo biosynthesis	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA STAT6-mediated induction of chemokines IRF3-mediated induction of type I IFN Neutrophil degranulation
Drugs		Pyridoxal Phosphate
Diseases
GWAS		Metabolite levels ( 23823483) Microalbuminuria ( 26631737)
Interacting Genes		3 interacting genes: DDX21 SRPK2 STING1	13 interacting genes: CCDC47 DDOST IRAK1 LTN1 MBOAT7 MUL1 RNF26 SGPL1 STT3A SURF4 TRIM32 USP20 USP49
Entrez ID		8879	340061
HPRD ID		07224	14173
Ensembl ID		ENSG00000166224	ENSG00000184584
Uniprot IDs		O95470	J3QTB1 Q86WV6 V5V0K2
PDB IDs		4Q6R	4EF4 4EF5 4EMT 4EMU 4F5D 4F5E 4F5W 4F5Y 4F9E 4F9G 4KSY 4LOH 4LOI 4QXO 4QXP 4QXQ 4QXR 5BQX 5JEJ 6CFF 6CY7 6DNK 6DXG 6DXL 6MX0 6MX3 6MXE 6NT5 6O8B 6O8C
Enriched GO Terms of Interacting Partners?
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