TERF2 and HEXIM1

Number of citations of the paper that reports this interaction (PubMedID 21044950)
41

Data Source:
BioGRID (two hybrid)

		TERF2	HEXIM1
Description		telomeric repeat binding factor 2	HEXIM P-TEFb complex subunit 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Nuclear Body Mre11 Complex Shelterin Complex Axon Cytoplasm	Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Protein C-terminus Binding Enzyme Binding Telomeric DNA Binding Protein Homodimerization Activity Protein-containing Complex Binding G-rich Strand Telomeric DNA Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	Telomere Maintenance RNA-dependent DNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Cell Cycle Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Telomere Capping Telomeric Loop Formation Protection From Non-homologous End Joining At Telomere Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Recombination Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Nitric-oxide Synthase Activity Telomeric D-loop Disassembly Protein Localization To Chromosome, Telomeric Region Cellular Senescence Anterograde Axonal Transport Of Messenger Ribonucleoprotein Complex Negative Regulation Of Beta-galactosidase Activity Negative Regulation Of Telomere Single Strand Break Repair Negative Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of T-circle Formation Negative Regulation Of Exonuclease Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Activation Of Innate Immune Response Heart Development Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase DNA Damage/Telomere Stress Induced Senescence
Drugs
Diseases
GWAS		Body mass index ( 26426971) Logical memory (delayed recall) in normal cognition ( 29274321) Pulse pressure ( 30578418)	Asthma ( 31619474) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)
Interacting Genes		59 interacting genes: AFAP1L2 ANXA5 APEX1 ASS1 ATM BANP BARD1 BLM CCDC137 CTBP1 DDX21 DDX24 EP300 GNMT H2AX HDGFL2 HEXIM1 HEXIM2 HMGB1 HMGN1 HMGN2 HMGN3 HMGN4 LANCL2 LYAR MAGOHB NAIF1 NASP NCL NUMA1 NUMB NUTF2 NXNL1 OCM2 ORC3 ORC6 PIAS1 PIK3R3 PPM1G PRMT1 PTMA RNF113A RNF4 RPL13 RPRD1B SET SIAH1 SP100 SRSF6 TALDO1 TERF2IP TINF2 TMSB10 TOR1AIP1 UBE2I WDR4 WRN XRCC6 ZC3H18	10 interacting genes: CCNT1 CCNT2 CDK9 EGFR ESR1 RELA RN7SK TERF1 TERF2 UBE2O
Entrez ID		7014	10614
HPRD ID		03610	09544
Ensembl ID		ENSG00000132604	ENSG00000186834
Uniprot IDs		Q15554	O94992
PDB IDs		1H6P 1VF9 1VFC 1W0U 1XG1 3BU8 3BUA 3K6G 3SJM 4M7C 4RQI 5WQD 5XYF 6J67	2GD7 3S9G
Enriched GO Terms of Interacting Partners?
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