MXI1 and SMC3

Number of citations of the paper that reports this interaction (PubMedID 9528857)
6

Data Source:
HPRD (in vitro)

		MXI1	SMC3
Description		MAX interactor 1, dimerization protein	structural maintenance of chromosomes 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytosol RNA Polymerase II Transcription Factor Complex	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity Protein Binding Protein Dimerization Activity	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Proliferation Cytoplasmic Sequestering Of Transcription Factor	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Regulation Of Mitotic Spindle Assembly
Pathways			Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases			Cornelia de Lange syndrome (CdLS)
GWAS		Birth weight ( 31043758) Diastolic blood pressure ( 30224653) Neutrophil count ( 29403010) Normalized brain volume ( 19010793) Platelet count ( 29403010) White blood cell count ( 29403010)	Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: APP CALCOCO2 ENTPD5 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 MAX MYC NOTCH2NLA RPL23AP32 SIN3A SIN3B SMARCB1 SMC3 USHBP1	17 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B TRAF3IP1
Entrez ID		4601	9126
HPRD ID		02486	05829
Ensembl ID		ENSG00000119950	ENSG00000108055
Uniprot IDs		A0A0S2Z3X5 P50539	Q9UQE7
PDB IDs
Enriched GO Terms of Interacting Partners?
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