CREB3L1 and FXYD6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CREB3L1	FXYD6
Description		cAMP responsive element binding protein 3 like 1	FXYD domain containing ion transport regulator 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Plasma Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding CAMP Response Element Binding Transcription Regulatory Region DNA Binding SMAD Binding	Molecular_function Protein Binding Sodium Channel Regulator Activity Ion Channel Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Multicellular Organism Development Negative Regulation Of Gene Expression Viral Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Extracellular Matrix Constituent Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Biological_process Ion Transmembrane Transport Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		CREB3 factors activate genes	Ion homeostasis Ion transport by P-type ATPases
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Fasting blood glucose ( 22581228) LDL cholesterol ( 30275531) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Schizophrenia ( 29483656) Systolic blood pressure ( 30578418)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965)
Interacting Genes		30 interacting genes: C5 CD99L2 CFHR5 CREB3 CREB3L3 CREM CYBC1 DDIT3 FAM3C FXYD3 FXYD6 GPR25 HIF1A JAGN1 MFSD5 NRM PGAP2 PGRMC1 PLN PLP1 PRKAB2 RUNX1T1 SLC30A8 SLC35B4 TMEM11 TMEM128 TMEM147 TMEM218 TMEM234 TSPO	15 interacting genes: BCAR1 C4BPA CCDC90B CREB3 CREB3L1 GDF9 HAUS2 LMNA PPP1CC RBM48 SLC35E1 TLE1 TP53 TRIM27 UNC119
Entrez ID		90993	53826
HPRD ID		16751	09456
Ensembl ID		ENSG00000157613	ENSG00000137726
Uniprot IDs		B2RA75 Q96BA8	A0A024R3J8 Q9H0Q3
PDB IDs
Enriched GO Terms of Interacting Partners?
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