FXYD6 and CREB3L1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FXYD6	CREB3L1
Description		FXYD domain containing ion transport regulator 6	cAMP responsive element binding protein 3 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Nuclear Chromatin Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Molecular_function Protein Binding Sodium Channel Regulator Activity Ion Channel Regulator Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding CAMP Response Element Binding Transcription Regulatory Region DNA Binding SMAD Binding
	Biological Process	Biological_process Ion Transmembrane Transport Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Multicellular Organism Development Negative Regulation Of Gene Expression Viral Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Extracellular Matrix Constituent Secretion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Ion homeostasis Ion transport by P-type ATPases	CREB3 factors activate genes
Drugs
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Fasting blood glucose ( 22581228) LDL cholesterol ( 30275531) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Schizophrenia ( 29483656) Systolic blood pressure ( 30578418)
Interacting Genes		15 interacting genes: BCAR1 C4BPA CCDC90B CREB3 CREB3L1 GDF9 HAUS2 LMNA PPP1CC RBM48 SLC35E1 TLE1 TP53 TRIM27 UNC119	30 interacting genes: C5 CD99L2 CFHR5 CREB3 CREB3L3 CREM CYBC1 DDIT3 FAM3C FXYD3 FXYD6 GPR25 HIF1A JAGN1 MFSD5 NRM PGAP2 PGRMC1 PLN PLP1 PRKAB2 RUNX1T1 SLC30A8 SLC35B4 TMEM11 TMEM128 TMEM147 TMEM218 TMEM234 TSPO
Entrez ID		53826	90993
HPRD ID		09456	16751
Ensembl ID		ENSG00000137726	ENSG00000157613
Uniprot IDs		A0A024R3J8 Q9H0Q3	B2RA75 Q96BA8
PDB IDs
Enriched GO Terms of Interacting Partners?
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