LRSAM1 and MUTYH

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		LRSAM1	MUTYH
Description		leucine rich repeat and sterile alpha motif containing 1	mutY DNA glycosylase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Protein Polyubiquitination Autophagy Protein Catabolic Process Negative Regulation Of Endocytosis Viral Budding Protein Autoubiquitination Ubiquitin-dependent Endocytosis Positive Regulation Of Xenophagy Positive Regulation Of Autophagosome Assembly	DNA Repair Base-excision Repair Mismatch Repair Depurination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Familial adenomatous polyposis
GWAS			Composite immunoglobulin trait (IgA/IgM) ( 28628107)
Interacting Genes		37 interacting genes: ATXN1 ATXN7 FAM178B GABARAPL2 GPR108 GRIK5 GSK3A KLC1 MAGEA1 MDM4 MGAT4B MKRN3 MUTYH MYL2 NINL PHF23 RNF111 RXRG TERF1 TNFRSF10C TRIM17 TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2H UBE2J1 UBE2K UBE2N UBE2W UEVLD USP2 USP21 VPS11	9 interacting genes: AGTRAP APEX1 LMNA LRSAM1 MSH6 PCNA RPA1 RPA4 SIRT6
Entrez ID		90678	4595
HPRD ID		14325	05380
Ensembl ID		ENSG00000148356	ENSG00000132781
Uniprot IDs		A0A024R870 Q6UWE0	D3DPZ6 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 Q9UIF7
PDB IDs			1X51 3N5N
Enriched GO Terms of Interacting Partners?
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