MUTYH and MSH6

Number of citations of the paper that reports this interaction (PubMedID 11801590)
59

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		MUTYH	MSH6
Description		mutY DNA glycosylase	mutS homolog 6
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Nuclear Chromatin Nucleus Nucleoplasm Golgi Apparatus Cytosol Mismatch Repair Complex MutSalpha Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Magnesium Ion Binding Four-way Junction DNA Binding Chromatin Binding Double-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity ATPase Activity Enzyme Binding Mismatched DNA Binding Guanine/thymine Mispair Binding Single Guanine Insertion Binding Single Thymine Insertion Binding Oxidized Purine DNA Binding MutLalpha Complex Binding Methylated Histone Binding Protein Homodimerization Activity ADP Binding
	Biological Process	DNA Repair Base-excision Repair Mismatch Repair Depurination	Meiotic Mismatch Repair DNA Repair Pyrimidine Dimer Repair Mismatch Repair Determination Of Adult Lifespan Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Viral Process Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Interstrand Cross-link Repair Maintenance Of DNA Repeat Elements Isotype Switching Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity Intrinsic Apoptotic Signaling Pathway
Pathways			Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6
Drugs
Diseases		Familial adenomatous polyposis	Colorectal cancer Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Composite immunoglobulin trait (IgA/IgM) ( 28628107)	General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Menopause (age at onset) ( 26414677) Takayasu arteritis ( 25604533) Tea consumption ( 31046077)
Interacting Genes		9 interacting genes: AGTRAP APEX1 LMNA LRSAM1 MSH6 PCNA RPA1 RPA4 SIRT6	13 interacting genes: BARD1 BRCA1 CHAF1A CREBBP CSNK2A1 EP300 HUS1 MSH2 MUTYH PCNA RAD1 RAD9A SMC1A
Entrez ID		4595	2956
HPRD ID		05380	07202
Ensembl ID		ENSG00000132781	ENSG00000116062
Uniprot IDs		D3DPZ6 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 Q9UIF7	P52701 Q3SWU9
PDB IDs		1X51 3N5N	2GFU 2O8B 2O8C 2O8D 2O8E 2O8F 6OQM
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?