MUTYH and SIRT6

Number of citations of the paper that reports this interaction (PubMedID 26063178)
8

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MUTYH	SIRT6
Description		mutY DNA glycosylase	sirtuin 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Nucleus Nucleoplasm Nuclear Telomeric Heterochromatin Nucleolus Cytoplasm
	Molecular Function	Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Protein Binding DNA N-glycosylase Activity Oxidized Purine DNA Binding MutLalpha Complex Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Adenine/guanine Mispair Binding Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	Chromatin Binding Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity NAD(P)+-protein-arginine ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity NAD-dependent Protein Deacetylase Activity NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD+ Binding
	Biological Process	DNA Repair Base-excision Repair Mismatch Repair Depurination	Negative Regulation Of Transcription By RNA Polymerase II Post-embryonic Cardiac Muscle Cell Growth Involved In Heart Morphogenesis Base-excision Repair Protein ADP-ribosylation Protein Deacetylation Negative Regulation Of Cell Proliferation Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Destabilization Response To Nutrient Levels Positive Regulation Of Chromatin Silencing At Telomere Positive Regulation Of Telomere Maintenance Glucose Homeostasis Negative Regulation Of Glycolytic Process Negative Regulation Of Glucose Import Positive Regulation Of Fibroblast Proliferation Histone H3-K9 Modification Histone H3 Deacetylation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Chondrocyte Proliferation Positive Regulation Of Telomeric Heterochromatin Assembly Positive Regulation Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Histone H3-K9 Deacetylation Positive Regulation Of Stem Cell Proliferation
Pathways			Pre-NOTCH Transcription and Translation Processing of DNA double-strand break ends
Drugs
Diseases		Familial adenomatous polyposis
GWAS		Composite immunoglobulin trait (IgA/IgM) ( 28628107)
Interacting Genes		9 interacting genes: AGTRAP APEX1 LMNA LRSAM1 MSH6 PCNA RPA1 RPA4 SIRT6	17 interacting genes: AKT1 CCNDBP1 CDKN1B CHD3 ELF5 FAF1 HUS1 MUTYH RAD1 SKP2 STUB1 TDG TSPYL2 UBE2D1 UBE3A USP10 VIM
Entrez ID		4595	51548
HPRD ID		05380	12093
Ensembl ID		ENSG00000132781	ENSG00000077463
Uniprot IDs		D3DPZ6 E5KP25 E5KP26 E5KP27 E5KP28 E9PM53 Q9UIF7	B4DDV3 M0QXA0 M0R1N9 Q8N6T7
PDB IDs		1X51 3N5N	3K35 3PKI 3PKJ 3ZG6 5MF6 5MFP 5MFZ 5MGN 5X16 5Y2F 6HOY
Enriched GO Terms of Interacting Partners?
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