RASA1 and ERBB4

Number of citations of the paper that reports this interaction (PubMedID 16273093)
240

Data Source:
BioGRID (unspecified method)

		RASA1	ERBB4
Description		RAS p21 protein activator 1	erb-b2 receptor tyrosine kinase 4
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane	Extracellular Region Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Integral Component Of Plasma Membrane Basal Plasma Membrane Basolateral Plasma Membrane Receptor Complex Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	MAPK Cascade Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process	MAPK Cascade Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Synapse Assembly Heart Development Lactation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Central Nervous System Morphogenesis Olfactory Bulb Interneuron Differentiation Regulation Of Cell Migration Positive Regulation Of Kinase Activity ERBB2 Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Mitochondrial Fragmentation Involved In Apoptotic Process Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JAK-STAT Cascade Protein Autophosphorylation Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Cardiac Muscle Cell Proliferation Mammary Gland Epithelial Cell Differentiation Mammary Gland Alveolus Development Cardiac Muscle Tissue Regeneration Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Localization To Cell Surface Regulation Of Cell Motility Negative Regulation Of Neuron Migration
Pathways		Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs			Afatinib Brigatinib
Diseases		RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS		Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (sex interaction) ( 24824216) Atrial fibrillation ( 30061737 29892015) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28892062 25673413) Body mass index (change over time) ( 25133637) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Breast cancer ( 22452962) Coronary artery calcification ( 23870195) Estimated glomerular filtration rate ( 31152163) Feeling fed-up ( 29500382) Feeling lonely ( 29500382) Glomerular filtration rate ( 29403010) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Liver fibrosis in non-alcoholic fatty acid liver disease ( 31311600) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Metabolite levels ( 23823483) Personality dimensions ( 23903073) Polycystic ovary syndrome ( 26416764) Positive urgency ( 30718321) QT interval (ambient particulate matter interaction) ( 28749367) Skin aging (microtopography measurement) ( 28502801) Sperm motility ( 29453196) Systolic blood pressure ( 30224653) Thyroxine levels ( 30843173) Total intracranial volume ( 31530798) Triiodothyronine levels ( 30843173) Type 1 diabetes nephropathy ( 23028342) Urate levels ( 31578528)
Interacting Genes		75 interacting genes: ABL1 AFAP1L2 ANXA6 APP ARHGAP1 ARHGAP5 AURKB BBS10 BCR BIRC5 CASP3 CASP7 CAV2 CD5 CSF1R CSK DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PTK2B PTPRC PXN RAB5A RACK1 RAP1A SERPINA4 SHC1 SLC9A2 SOCS3 SPSB1 SRC STAU1 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579	70 interacting genes: ABL1 ABL2 ADAM17 ANKS1A ANKS1B BTC CCN2 CD44 CDC25C CRK DLG1 DLG2 DLG3 DLG4 DUSP10 DUSP14 DUSP16 DUSP18 DUSP19 DUSP21 DUSP6 EGFR ERBB2 ERBB3 EREG GRB2 HBEGF HDAC6 ILKAP ITCH MTMR2 MTMR6 MTMR9 MUC1 MUC4 NEDD4 NRG1 NRG2 NRG3 NRG4 NTRK2 PIK3R2 PPM1A PPM1B PPM1F PTPDC1 PTPN11 PTPN12 PTPN20 PTPN21 PTPN6 PTPN7 PTPRH PTPRR PTPRT RASA1 RNF41 SHC1 SNTB2 STAT5A STAT5B STYX SYK TAB1 TAB2 TFAP2C TGFA TRO WWOX YAP1
Entrez ID		5921	2066
HPRD ID		00745	02767
Ensembl ID		ENSG00000145715	ENSG00000178568
Uniprot IDs		P20936 Q59GK3	Q15303
PDB IDs		1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS	2AHX 2L2T 2LCX 2R4B 3BBT 3BBW 3BCE 3U2P 3U7U 3U9U
Enriched GO Terms of Interacting Partners?
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