RASA1 and BCR

Number of citations of the paper that reports this interaction (PubMedID 1383690)
21

Data Source:
HPRD (in vitro)

		RASA1	BCR
Description		RAS p21 protein activator 1	BCR activator of RhoGEF and GTPase
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Plasma Membrane	Cytosol Plasma Membrane Postsynaptic Density Membrane Cell Junction Axon Protein-containing Complex Dendritic Spine Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding ATP Binding Kinase Activity
	Biological Process	MAPK Cascade Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process	Negative Regulation Of Cellular Extravasation Renal System Process Protein Phosphorylation Signal Transduction Small GTPase Mediated Signal Transduction Brain Development Actin Cytoskeleton Organization Keratinocyte Differentiation Regulation Of Rho Protein Signal Transduction Inner Ear Morphogenesis Regulation Of Vascular Permeability Negative Regulation Of Neutrophil Degranulation Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Homeostasis Of Number Of Cells Negative Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Modulation Of Chemical Synaptic Transmission Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cell Cycle Definitive Hemopoiesis Negative Regulation Of Respiratory Burst Negative Regulation Of Blood Vessel Remodeling Intracellular Protein Transmembrane Transport Cellular Response To Lipopolysaccharide Activation Of GTPase Activity Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Signaling by cytosolic FGFR1 fusion mutants Rho GTPase cycle Signaling by FGFR1 in disease
Drugs			Dasatinib Bosutinib Ponatinib
Diseases		RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)	Chronic myeloid leukemia (CML) Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)	Asthma ( 27611488) Coenzyme Q10 levels ( 27149984) Height ( 18391951) Immune response to smallpox vaccine (IL-6) ( 22542470) Kidney stones ( 31729369)
Interacting Genes		75 interacting genes: ABL1 AFAP1L2 ANXA6 APP ARHGAP1 ARHGAP5 AURKB BBS10 BCR BIRC5 CASP3 CASP7 CAV2 CD5 CSF1R CSK DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PTK2B PTPRC PXN RAB5A RACK1 RAP1A SERPINA4 SHC1 SLC9A2 SOCS3 SPSB1 SRC STAU1 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579	45 interacting genes: ABL1 ABL2 AFDN APBA3 BLK CBL CDC42 CRK CRKL DLG1 DOK1 ERCC3 FES GRB10 GRB2 HCK HNF1A IGSF21 IRS1 JAK2 LNX1 MAP4K5 PLCG1 PTPN1 PTPN11 PTPN6 RAC1 RAD51 RASA1 RHOA SFN SHC1 SRC STUB1 TP53 TSG101 UBC UNC119 VAV1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		5921	613
HPRD ID		00745	01044
Ensembl ID		ENSG00000145715	ENSG00000186716
Uniprot IDs		P20936 Q59GK3	P11274
PDB IDs		1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS	1K1F 2AIN 5N6R 5N7E 5OC7
Enriched GO Terms of Interacting Partners?
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