OTULIN and FAM168A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		OTULIN	FAM168A
Description		OTU deubiquitinase with linear linkage specificity	family with sequence similarity 168 member A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol LUBAC Complex
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity	Protein Binding
	Biological Process	Sprouting Angiogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination	Positive Regulation Of Base-excision Repair
Pathways		Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058)	Blood protein levels ( 28240269) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30061609) Pulmonary function (smoking interaction) ( 23284291) Waist-hip ratio ( 28552196)
Interacting Genes		6 interacting genes: BCL10 DAZAP2 DVL2 FAM168A SPATA2 VCP	24 interacting genes: C1orf94 CALCOCO2 DAB1 DAZAP2 DTX2 FBXW5 HGS KLHL42 NAF1 OTUB2 OTULIN PRR20A R3HDM2 RBFOX1 RBPMS SF1 SMAP2 SNRPC SS18L1 TAX1BP1 TNIP1 UBASH3B UBE2V1 VPS37C
Entrez ID		90268	23201
HPRD ID		14266	13792
Ensembl ID		ENSG00000154124	ENSG00000054965
Uniprot IDs		Q96BN8	Q92567
PDB IDs		3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK
Enriched GO Terms of Interacting Partners?
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