SOCS3 and NME4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SOCS3	NME4
Description		suppressor of cytokine signaling 3	NME/NM23 nucleoside diphosphate kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Phosphatidylinositol 3-kinase Complex	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix
	Molecular Function	Phosphotyrosine Residue Binding Protein Kinase Inhibitor Activity Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Metal Ion Binding Cardiolipin Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Negative Regulation Of Inflammatory Response Regulation Of Interferon-gamma-mediated Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation Interleukin-6-mediated Signaling Pathway Cellular Response To Leukemia Inhibitory Factor	Purine Nucleotide Metabolic Process Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process Pyrimidine Nucleotide Metabolic Process UTP Biosynthetic Process CTP Biosynthetic Process Lipid Transport Nucleoside Metabolic Process Nucleobase-containing Small Molecule Interconversion Regulation Of Apoptotic Process
Pathways		Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	Interconversion of nucleotide di- and triphosphates
Drugs
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Creatine kinase levels ( 29403010)	Body mass index ( 26426971) Red blood cell traits ( 23446634)
Interacting Genes		54 interacting genes: ABL1 ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR ELOB ELOC EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRF7 IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RNF7 RPL7A SH2D2A SOCS2 TES TFDP1 TFR2 TRDN TXNDC11 YES1 YWHAQ	8 interacting genes: CLNK LSM8 NME1 NME1-NME2 SOCS3 SUV39H2 TNS4 TRIP13
Entrez ID		9021	4833
HPRD ID		05006	03489
Ensembl ID		ENSG00000184557	ENSG00000103202
Uniprot IDs		O14543 Q6FI39	A0A087WVT9 O00746
PDB IDs			1EHW
Enriched GO Terms of Interacting Partners?
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