FATE1 and CSF2RA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FATE1	CSF2RA
Description		fetal and adult testis expressed 1	colony stimulating factor 2 receptor subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondria-associated ER Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity
	Biological Process	Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitochondrial Calcium Ion Concentration	MAPK Cascade Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process
Pathways			Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) Interleukin receptor SHC signaling
Drugs			Sargramostim KB002 recombinant human GM-CSF
Diseases
GWAS		Systemising ( 31508503)	Schizophrenia ( 17522711)
Interacting Genes		57 interacting genes: AGTRAP AQP9 ATCAY BCL2L2 BIK BNIP2 BNIP3 BNIP3L BSND BTN2A2 CCDC70 CD302 CD79A CSF2RA CXCR3 DCTN5 EMD GPR25 INPP5K KASH5 KCNS2 LMNA LNPEP MARCHF2 MARCHF5 MR1 NDUFB11 NRG4 NRSN1 OCLN PIN4 PRRG2 RNF183 RPRM SEC22A SEC22C SEC23B SLC38A1 SLC7A1 SMIM14 SNAP47 SYNDIG1 SYNE4 SYNGR1 SYNGR2 SYNPR TBP TIMMDC1 TM4SF4 TMEM11 TMEM74 TRAF2 TRAF3IP3 USHBP1 USP20 YIPF2 YIPF4	9 interacting genes: CHUK CSF2 CSF2RB FATE1 IKBKB KIT LYN PIK3R1 RPSA
Entrez ID		89885	1438
HPRD ID		02346	02381
Ensembl ID		ENSG00000147378	ENSG00000198223
Uniprot IDs		Q969F0	P15509
PDB IDs			4NKQ 4RS1
Enriched GO Terms of Interacting Partners?
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