HERC3 and CD33

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HERC3	CD33
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 3	CD33 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoplasmic Vesicle	Nucleoplasm Peroxisome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Specific Granule Membrane Tertiary Granule Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity	Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity
	Biological Process	Protein Ubiquitination	Immune Response-inhibiting Signal Transduction Cell Adhesion Signal Transduction Cell-cell Signaling Negative Regulation Of Cell Proliferation Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Neutrophil Degranulation Positive Regulation Of Protein Secretion Regulation Of Immune Response Negative Regulation Of Calcium Ion Transport Cell-cell Adhesion Positive Regulation Of Protein Tyrosine Phosphatase Activity
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs			Gemtuzumab ozogamicin
Diseases
GWAS		Hair greying ( 26926045) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Alzheimer's disease ( 18976728 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood protein levels ( 30072576 29875488 28240269) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) HIV-1 susceptibility ( 25786224) Platelet count ( 27863252) Plateletcrit ( 27863252) Triacylglyceride levels ( 31551469) White blood cell count ( 27863252)
Interacting Genes		13 interacting genes: CCL22 CD33 HERC6 NME2 SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2	6 interacting genes: HERC3 KRT31 KRT40 PTPN11 PTPN6 SRC
Entrez ID		8916	945
HPRD ID		16093	01165
Ensembl ID		ENSG00000138641	ENSG00000105383
Uniprot IDs		B4DK41 H0Y8G9 Q15034	P20138 Q546G0
PDB IDs			5IHB 5J06 5J0B 6D48 6D49 6D4A
Enriched GO Terms of Interacting Partners?
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