HERC3 and UBQLN2

Number of citations of the paper that reports this interaction (PubMedID 18535780)
13

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HERC3	UBQLN2
Description		HECT and RLD domain containing E3 ubiquitin protein ligase 3	ubiquilin 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoplasmic Vesicle	Nucleus Cytoplasm Autophagosome Cytosol Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Ubiquitin-protein Transferase Activity	Protein Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Protein Ubiquitination	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Ubiquitin-dependent ERAD Pathway Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Autophagosome Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Hair greying ( 26926045) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		13 interacting genes: CCL22 CD33 HERC6 NME2 SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2	22 interacting genes: ADRM1 ATXN7 BTRC C1QA CD93 FBXO25 FUS HERC3 HERPUD1 HNRNPA3 HSPA13 MTNR1B PRPF40A PSMA2 PSMA5 PSMD4 RNF11 RPN1 SMURF1 UBC UBE3A UBQLN4
Entrez ID		8916	29978
HPRD ID		16093	02224
Ensembl ID		ENSG00000138641	ENSG00000188021
Uniprot IDs		B4DK41 H0Y8G9 Q15034	Q9UHD9
PDB IDs			1J8C 2NBV 6MUN
Enriched GO Terms of Interacting Partners?
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