NR1I2 and TFAP2C

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		NR1I2	TFAP2C
Description		nuclear receptor subfamily 1 group I member 2	transcription factor AP-2 gamma
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Nuclear Body Intermediate Filament Cytoskeleton RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Xenobiotic Metabolic Process Signal Transduction Multicellular Organism Development Steroid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Response To Lipid Cholesterol Homeostasis Exogenous Drug Catabolic Process Xenobiotic Transport Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Lipid Homeostasis Cellular Response To Lipopolysaccharide	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Male Gonad Development Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways			SUMOylation of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors
Drugs		Vitamin E Oxiconazole Phenytoin Diethylstilbestrol Clotrimazole Pentobarbital Progesterone Spironolactone Lindane Flutamide Ritonavir Erlotinib Cyclophosphamide Mephenytoin Carbamazepine Tamoxifen Warfarin Ethotoin Estradiol Mifepristone Methylphenobarbital Ethinyl Estradiol Ketoconazole Fenofibrate Rifampicin Clonazepam Miconazole Nifedipine Econazole Sulfinpyrazone Phenobarbital Ifosfamide Rifaximin Paclitaxel Dexamethasone Docetaxel Bezafibrate Genistein Prasterone Hyperforin Resveratrol Pregnenolone Quercetin SR12813 Afimoxifene Phenolphthalein Permethrin Chenodeoxycholic acid N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE Hexestrol Triclosan Rilpivirine Pyrethrum extract Myrrh Piperine Troleandomycin
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Total cholesterol levels ( 30275531)	Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 31152163) Cerebrospinal P-tau181p levels ( 28247064) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Cognitive decline rate in late mild cognitive impairment ( 26252872) Ovarian cancer ( 30557369)
Interacting Genes		32 interacting genes: ACTN2 ATP6AP1 CHMP1A DNMT3L DYRK2 EP300 FGR HNF4A MAPK7 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NFATC4 NR0B2 NR5A2 NUCB2 POU1F1 PPARGC1A PSMC5 RBCK1 RPS6KB1 RXRA RXRB RXRG SDF4 SRC TADA3 TFAP2C UBE2I UBR5	12 interacting genes: CCNG1 CITED1 CITED2 CITED4 ERBB4 GPR22 IKBKB NR1I2 TP53 UBE2I WWOX ZFAND4
Entrez ID		8856	7022
HPRD ID		04346	03361
Ensembl ID		ENSG00000144852	ENSG00000087510
Uniprot IDs		F1D8P9 O75469	Q92754
PDB IDs		1ILG 1ILH 1M13 1NRL 1SKX 2O9I 2QNV 3CTB 3HVL 3R8D 4J5W 4J5X 4NY9 4S0S 4S0T 4X1F 4X1G 4XAO 4XHD 5A86 5X0R 6BNS 6DUP 6S41
Enriched GO Terms of Interacting Partners?
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