TRIM24 and BRD7

Number of citations of the paper that reports this interaction (PubMedID 19909775)
29

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		TRIM24	BRD7
Description		tripartite motif containing 24	bromodomain containing 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin Perichromatin Fibrils Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	P53 Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Nuclear Receptor Binding Estrogen Response Element Binding Methylated Histone Binding Ubiquitin Protein Ligase Activity Lysine-acetylated Histone Binding	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Histone Binding Transcription Regulatory Region DNA Binding Lysine-acetylated Histone Binding
	Biological Process	Transcription By RNA Polymerase II Negative Regulation Of Cell Proliferation Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator	Regulation Of Transcription By RNA Polymerase II Cell Cycle Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions	Regulation of TP53 Activity through Acetylation
Drugs
Diseases
GWAS		Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Quantitative traits ( 19197348)	Allergic sensitization ( 30013184) Epilepsy ( 30531953) Liver enzyme levels (alanine transaminase) ( 24124411) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		50 interacting genes: AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 ESR1 ESR2 FBN2 FOSL1 GTF2E1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 HNF4A HSPA1A HSPB1 MTNR1B NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML PPARG RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRIM28 TRIM33 TRIM8 UBE2I UBE2U VDR ZNF10	30 interacting genes: AGR2 BARD1 BHLHE40 BRD3 BTBD2 DVL1 FTH1 H2AC16 H2BC21 H3-3A H3-4 H3C14 H4-16 HAP1 HNRNPUL1 IRF2 LAMA4 LRIF1 MX1 NEFL PAFAH1B3 PCBD1 PSMD11 PTPN13 RBFOX2 RIF1 RPLP1 SERPINB9 TP53 TRIM24
Entrez ID		8805	29117
HPRD ID		04556	12531
Ensembl ID		ENSG00000122779	ENSG00000166164
Uniprot IDs		A0A024R784 O15164	Q9NPI1
PDB IDs		2YYN 3O33 3O34 3O35 3O36 3O37 4YAB 4YAD 4YAT 4YAX 4YBM 4YBS 4YBT 4YC9 4ZQL 5H1T 5H1U 5H1V	2I7K 5MQ1
Enriched GO Terms of Interacting Partners?
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