CBS and PRKAG1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CBS	PRKAG1
Description		cystathionine beta-synthase	protein kinase AMP-activated non-catalytic subunit gamma 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex
	Molecular Function	Cystathionine Beta-synthase Activity Cysteine Synthase Activity Protein Binding Oxygen Binding Enzyme Binding Heme Binding Pyridoxal Phosphate Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Nitrite Reductase (NO-forming) Activity Carbon Monoxide Binding Nitric Oxide Binding Modified Amino Acid Binding S-adenosyl-L-methionine Binding	Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding
	Biological Process	Cysteine Biosynthetic Process From Serine L-serine Metabolic Process L-serine Catabolic Process Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration L-cysteine Catabolic Process DNA Protection Homocysteine Catabolic Process Homocysteine Metabolic Process Oxidation-reduction Process Hydrogen Sulfide Biosynthetic Process	Regulation Of Glycolytic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Cell Cycle Arrest Signal Transduction Spermatogenesis Positive Regulation Of Gene Expression Macroautophagy Regulation Of Macroautophagy Positive Regulation Of Protein Kinase Activity Import Into Nucleus Regulation Of Signal Transduction By P53 Class Mediator Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Cysteine formation from homocysteine Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs		Pyridoxal Phosphate Ademetionine Serine L-Cysteine	Acetylsalicylic acid
Diseases		Homocystinuria
GWAS		Blood and toenail selenium levels ( 25343990) Blood metabolite levels ( 24816252) Blood trace element (Se levels) ( 23720494) Homocysteine levels ( 23824729 20031578) Obesity-related traits ( 23251661) Plasma homocysteine levels (post-methionine load test) ( 24651765) Pre-treatment viral load in HIV-1 infection ( 31219150)	Bipolar disorder ( 31043756) Body mass index ( 29273807) HDL cholesterol ( 30275531) Pulse pressure ( 27618447) Systolic blood pressure ( 27618447 30578418)
Interacting Genes		21 interacting genes: CBX4 CERT1 DAXX EHHADH FXR2 HGS HID1 HTT NTAQ1 PIAS1 PIAS3 PIN1 PRKAG1 PRKAR1A PSMA1 RANBP9 UBASH3A UBE2I UGP2 VTA1 ZDHHC17	16 interacting genes: ACACA AP1S3 C1orf94 CBS EIF3G KCNN4 KEAP1 KRTAP10-3 KRTAP4-2 PAICS PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 TEKT1
Entrez ID		875	5571
HPRD ID		01994	04118
Ensembl ID		ENSG00000160200	ENSG00000181929
Uniprot IDs		B7Z2D6 P0DN79 P35520 Q9NTF0	A0A024R125 P54619
PDB IDs		1JBQ 1M54 4COO 4L0D 4L27 4L28 4L3V 4PCU 4UUU 5MMS	2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J
Enriched GO Terms of Interacting Partners?
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