SHANK3 and NCK1

  • Number of citations of the paper that reports this interaction (PubMedID 21988832)
  • 75
  • Data Source:
  • BioGRID (two hybrid)

SHANK3

NCK1

Description SH3 and multiple ankyrin repeat domains 3 NCK adaptor protein 1
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Blood protein levels ( 30072576)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Extremely high intelligence ( 29520040)
  • Fibrinogen ( 23969696)
  • Fibrinogen levels ( 28107422 26561523)
  • Intelligence (MTAG) ( 29326435)
  • Memory dysfunction in frontotemporal lobe dementia ( 29724592)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199)
  • Blood urea nitrogen levels ( 31152163)
  • Body mass index ( 25673413)
  • Schizophrenia ( 25056061 29483656)
Interacting Genes 17 interacting genes: ABCC2 CNKSR2 COPS5 CRKL CSNK2B DLGAP1 DLGAP2 DLGAP3 DLGAP4 GRB2 MAPK1 NCK1 PAX6 PPP1CC RPS6KA1 SPTAN1 USP8 86 interacting genes: ABI1 ABI2 ABL1 ADAM15 ADGRL2 ARHGAP32 ARHGEF7 BCAR1 BLNK BRK1 CAV2 CBL CBLB CD3E CRK CSNK1G2 CYFIP2 DAG1 DCC DNM1 DOK1 DOK2 DRD3 DRD4 EFS EGFR EIF2B2 EIF2S2 EPHB1 EPHB2 ERBB3 FASLG FCHO1 FGFR1 FLT1 FLT3 FRS2 GAB2 GMPPA HOMEZ KDR KHDRBS1 KIAA1522 LCP2 MAP4K1 MAP4K4 MINK1 NCKAP1 NCKAP5 NCKIPSD NEDD9 NPHS1 NTRK2 NUTM2F OLIG1 PAK1 PAK2 PAK3 PDGFRB PFN1 PHC2 PIK3R3 PKN2 PLCG1 PTK2 PXN RAC1 RASA1 RHOU RRAS SH2D1A SHANK3 SOCS1 SOCS7 SORBS3 SOS1 SYNJ2 SYNPO TBK1 TNIK TNK2 UBA52 WAS WASF1 WASL WIPF1
Entrez ID 85358 4690
HPRD ID 18979 02740
Ensembl ID ENSG00000251322 ENSG00000158092
Uniprot IDs A0A0S2Z4Y3 P16333
PDB IDs 2CI8 2CI9 2CUB 2JS0 2JS2 2JW4
Enriched GO Terms of Interacting Partners?
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