SHANK3 and CRKL

  • Number of citations of the paper that reports this interaction (PubMedID 21988832)
  • 75
  • Data Source:
  • BioGRID (two hybrid)

SHANK3

CRKL

Description SH3 and multiple ankyrin repeat domains 3 CRK like proto-oncogene, adaptor protein
Image No pdb structure
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Blood protein levels ( 30072576)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Extremely high intelligence ( 29520040)
  • Fibrinogen ( 23969696)
  • Fibrinogen levels ( 28107422 26561523)
  • Intelligence (MTAG) ( 29326435)
  • Memory dysfunction in frontotemporal lobe dementia ( 29724592)
  • Platelet distribution width ( 27863252)
Interacting Genes 17 interacting genes: ABCC2 CNKSR2 COPS5 CRKL CSNK2B DLGAP1 DLGAP2 DLGAP3 DLGAP4 GRB2 MAPK1 NCK1 PAX6 PPP1CC RPS6KA1 SPTAN1 USP8 75 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RIN3 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 WAC WAS WIPF1 YY1
Entrez ID 85358 1399
HPRD ID 18979 03596
Ensembl ID ENSG00000251322 ENSG00000099942
Uniprot IDs P46109
PDB IDs 2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?
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