CRKL and IFNAR1

Number of citations of the paper that reports this interaction (PubMedID 11167825)
7

Data Source:
HPRD (in vivo, in vitro)

		CRKL	IFNAR1
Description		CRK like proto-oncogene, adaptor protein	interferon alpha and beta receptor subunit 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Neuromuscular Junction Protein-containing Complex Extrinsic Component Of Postsynaptic Membrane	Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Phosphotyrosine Residue Binding RNA Binding SH3/SH2 Adaptor Activity Protein Binding Identical Protein Binding Cadherin Binding	Cytokine Receptor Activity Type I Interferon Receptor Activity Protein Binding Type I Interferon Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Regulation Of Cell Growth Blood Vessel Development Urogenital System Development Neuron Migration B Cell Apoptotic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Lipid Metabolic Process JNK Cascade Ras Protein Signal Transduction Spermatogenesis Single Fertilization Synapse Assembly Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Anterior/posterior Pattern Specification Negative Regulation Of Gene Expression Dendrite Development Cytokine-mediated Signaling Pathway Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Helper T Cell Diapedesis Reelin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Retinoic Acid Receptor Signaling Pathway Thymus Development Regulation Of Dendrite Development T Cell Receptor Signaling Pathway Parathyroid Gland Development Cell Chemotaxis Pharynx Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Endothelin Receptor Signaling Pathway Activation Of GTPase Activity Acetylcholine Receptor Signaling Pathway Cerebellar Neuron Development Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Glial Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cranial Skeletal System Development Regulation Of T Cell Migration	JAK-STAT Cascade Response To Virus Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Type I Interferon Signaling Pathway
Pathways		Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL	Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling
Drugs			Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant Natural alpha interferon omega interferon
Diseases
GWAS		Platelet distribution width ( 27863252)	Blood protein levels ( 30072576 29875488) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		75 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RIN3 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 WAC WAS WIPF1 YY1	24 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LCK MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		1399	3454
HPRD ID		03596	00126
Ensembl ID		ENSG00000099942	ENSG00000142166
Uniprot IDs		P46109	A0A494C0E2 P17181
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW	3S98 3SE3 3SE4 4PO6
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?