COPS3 and COPS2

Number of citations of the paper that reports this interaction (PubMedID 11337588)
231

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		COPS3	COPS2
Description		COP9 signalosome subunit 3	COP9 signalosome subunit 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome
	Molecular Function	Protein Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition In Utero Embryonic Development Transcription-coupled Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus Post-translational Protein Modification	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Inner Cell Mass Cell Proliferation Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Post-translational Protein Modification Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS			Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		24 interacting genes: ARAF CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS8 COPS9 CSNK2A1 CSNK2B CUL5 GPS1 IKBKB IKBKG IL1RN IRF5 ITGB2 LRP2BP MCPH1 MLF1 RAF1 SOS1 TP53	35 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CUL1 CUL5 DDB1 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 PRKD1 RARA RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR
Entrez ID		8533	9318
HPRD ID		07262	05146
Ensembl ID		ENSG00000141030	ENSG00000166200
Uniprot IDs		B4DN01 Q9UNS2	P61201 Q59EL2
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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