DGKD and HAX1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DGKD	HAX1
Description		diacylglycerol kinase delta	HCLS1 associated protein X-1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	P-body Nuclear Envelope Transcription Factor Complex Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Plasma Membrane Cell Cortex Actin Cytoskeleton Sarcoplasmic Reticulum Lamellipodium Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Kinase Binding Diacylglycerol Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Interleukin-1 Binding Protein N-terminus Binding
	Biological Process	Endocytosis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Response To Organic Substance Protein Transport Second-messenger-mediated Signaling Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation	Mitochondrion Organization Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Effects of PIP2 hydrolysis
Drugs		Phosphatidyl serine
Diseases			Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Bilirubin levels ( 20639394) Calcium levels ( 24068962 29403010 20705733) Crohn's disease ( 22412388) Glaucoma (primary open-angle) ( 29891935) Kidney stones ( 31729369) Plateletcrit ( 27863252) Total body bone mineral density ( 29304378) Type 2 diabetes ( 30718926) Urinary calcium excretion ( 31993563)	Bipolar disorder ( 31043756) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Serum total protein level ( 29403010)
Interacting Genes		7 interacting genes: DGKH HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14	26 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL UBAP2L YWHAQ ZNF420 ZNRD1
Entrez ID		8527	10456
HPRD ID		03492	12075
Ensembl ID		ENSG00000077044	ENSG00000143575
Uniprot IDs		A0A024R495 Q16760	A0A0S2Z565 A0A0S2Z591 O00165
PDB IDs		1R79 3BQ7
Enriched GO Terms of Interacting Partners?
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