FIZ1 and FLT3

Number of citations of the paper that reports this interaction (PubMedID 10409713)
5

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		FIZ1	FLT3
Description		FLT3 interacting zinc finger 1	fms related receptor tyrosine kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Nucleic Acid Binding Receptor Tyrosine Kinase Binding Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Glucocorticoid Receptor Binding Protein Self-association Protein-containing Complex Binding
	Biological Process	Positive Regulation Of Protein Phosphorylation	MAPK Cascade Leukocyte Homeostasis Hematopoietic Progenitor Cell Differentiation Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Leukocyte Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis Lymphocyte Differentiation B Cell Differentiation Animal Organ Regeneration Positive Regulation Of Kinase Activity Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Lymphocyte Proliferation Protein Autophosphorylation Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation
Pathways			PI3K Cascade RAF/MAP kinase cascade FLT3 Signaling FLT3 Signaling STAT5 Activation
Drugs			Sorafenib Sunitinib XL999 Tandutinib ABT-869 Midostaurin Ponatinib Nintedanib Brigatinib Amuvatinib Quizartinib
Diseases			Acute myeloid leukemia (AML)
GWAS		Periodontitis (Mean PAL) ( 24024966)	Body mass index ( 25673413 29273807) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 25086665) Psoriasis ( 25854761) Rapid automised naming of digits ( 30741946) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Tourette syndrome ( 30818990) White blood cell count ( 27863252) White blood cell count (monocyte) ( 28158719)
Interacting Genes		2 interacting genes: FLT3 NRL	17 interacting genes: CBL CBLB ERBB2 FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN11 PTPN12 PTPN6 SH3BP2 SLA SOCS1 SRC UBE2L6
Entrez ID		84922	2322
HPRD ID		07870	00635
Ensembl ID		ENSG00000179943	ENSG00000122025
Uniprot IDs		Q96SL8	P36888
PDB IDs			1RJB 3QS7 3QS9 4RT7 4XUF 5X02 6IL3 6JQR
Enriched GO Terms of Interacting Partners?
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