FLT3 and PTPN12

Number of citations of the paper that reports this interaction (PubMedID 15831474)
39

Data Source:
HPRD (in vitro)

		FLT3	PTPN12
Description		fms related receptor tyrosine kinase 3	protein tyrosine phosphatase non-receptor type 12
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Podosome Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Cell Projection
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Glucocorticoid Receptor Binding Protein Self-association Protein-containing Complex Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding
	Biological Process	MAPK Cascade Leukocyte Homeostasis Hematopoietic Progenitor Cell Differentiation Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Leukocyte Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis Lymphocyte Differentiation B Cell Differentiation Animal Organ Regeneration Positive Regulation Of Kinase Activity Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Lymphocyte Proliferation Protein Autophosphorylation Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Tissue Regeneration Cellular Response To Cytokine Stimulus Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		PI3K Cascade RAF/MAP kinase cascade FLT3 Signaling FLT3 Signaling STAT5 Activation	SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling EGFR downregulation Signaling by PDGF Downregulation of ERBB2 signaling Interleukin-37 signaling Constitutive Signaling by Overexpressed ERBB2
Drugs		Sorafenib Sunitinib XL999 Tandutinib ABT-869 Midostaurin Ponatinib Nintedanib Brigatinib Amuvatinib Quizartinib
Diseases		Acute myeloid leukemia (AML)
GWAS		Body mass index ( 25673413 29273807) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 25086665) Psoriasis ( 25854761) Rapid automised naming of digits ( 30741946) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Tourette syndrome ( 30818990) White blood cell count ( 27863252) White blood cell count (monocyte) ( 28158719)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		17 interacting genes: CBL CBLB ERBB2 FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN11 PTPN12 PTPN6 SH3BP2 SLA SOCS1 SRC UBE2L6	48 interacting genes: AATK ABL1 APP BAG6 BCAR1 CGA CSH1 CSH2 CSK EFS EGFR EIF4H ERBB3 ERBB4 FGFR2 FGFR4 FLT3 GRB2 IFT20 IGF1R INSR JAK2 KDR LMTK2 LPXN MYCBP2 NEDD9 PRKACA PRKCA PSG9 PSTPIP1 PSTPIP2 PTK2 PTK2B PTK7 PXN RBM19 ROR2 SHC1 SMAD5 SORBS2 STX16 TEX10 TGFB1I1 THAP2 UTRN WAS ZFP2
Entrez ID		2322	5782
HPRD ID		00635	02513
Ensembl ID		ENSG00000122025	ENSG00000127947
Uniprot IDs		P36888	B4E105 Q05209
PDB IDs		1RJB 3QS7 3QS9 4RT7 4XUF 5X02 6IL3 6JQR	5HDE 5J8R 5O2P
Enriched GO Terms of Interacting Partners?
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