FLT3 and FLT3LG

Number of citations of the paper that reports this interaction (PubMedID 7505204)
76

Data Source:
HPRD (in vivo)

		FLT3	FLT3LG
Description		fms related receptor tyrosine kinase 3	fms related receptor tyrosine kinase 3 ligand
Image
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space Cell Surface Membrane Integral Component Of Membrane Intrinsic Component Of External Side Of Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Growth Factor Binding Glucocorticoid Receptor Binding Protein Self-association Protein-containing Complex Binding	Signaling Receptor Binding Cytokine Activity Receptor Tyrosine Kinase Binding
	Biological Process	MAPK Cascade Leukocyte Homeostasis Hematopoietic Progenitor Cell Differentiation Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Leukocyte Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis Lymphocyte Differentiation B Cell Differentiation Animal Organ Regeneration Positive Regulation Of Kinase Activity Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Lymphocyte Proliferation Protein Autophosphorylation Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation	MAPK Cascade Positive Regulation Of Protein Phosphorylation Signal Transduction Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Lymphocyte Differentiation Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Embryonic Hemopoiesis Positive Regulation Of Myoblast Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Apoptotic Process In Bone Marrow Positive Regulation Of Osteoclast Proliferation Positive Regulation Of Myoblast Fusion
Pathways		PI3K Cascade RAF/MAP kinase cascade FLT3 Signaling FLT3 Signaling STAT5 Activation	PI3K Cascade RAF/MAP kinase cascade FLT3 Signaling FLT3 Signaling STAT5 Activation
Drugs		Sorafenib Sunitinib XL999 Tandutinib ABT-869 Midostaurin Ponatinib Nintedanib Brigatinib Amuvatinib Quizartinib
Diseases		Acute myeloid leukemia (AML)
GWAS		Body mass index ( 25673413 29273807) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 25086665) Psoriasis ( 25854761) Rapid automised naming of digits ( 30741946) Serum total protein level ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Tourette syndrome ( 30818990) White blood cell count ( 27863252) White blood cell count (monocyte) ( 28158719)	Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		17 interacting genes: CBL CBLB ERBB2 FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN11 PTPN12 PTPN6 SH3BP2 SLA SOCS1 SRC UBE2L6	3 interacting genes: FLT3 KITLG PFN2
Entrez ID		2322	2323
HPRD ID		00635	02477
Ensembl ID		ENSG00000122025	ENSG00000090554
Uniprot IDs		P36888	B7ZLY4 M0QYM9 P49771
PDB IDs		1RJB 3QS7 3QS9 4RT7 4XUF 5X02 6IL3 6JQR	1ETE 3QS7 3QS9
Enriched GO Terms of Interacting Partners?
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