OGT and HIRA

Number of citations of the paper that reports this interaction (PubMedID 27217568)
9

Data Source:
BioGRID (pull down)

		OGT	HIRA
Description		O-linked N-acetylglucosamine (GlcNAc) transferase	histone cell cycle regulator
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GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytosol Plasma Membrane Protein N-acetylglucosaminyltransferase Complex Mitochondrial Membrane Protein-containing Complex Cell Projection	HIR Complex Chromosome, Centromeric Region Nuclear Chromatin Nucleus Nucleoplasm PML Body Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Acetylglucosaminyltransferase Activity Protein N-acetylglucosaminyltransferase Activity Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific) Protein O-GlcNAc Transferase Activity	DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding
	Biological Process	Regulation Of Glycolytic Process Regulation Of Gluconeogenesis Regulation Of Transcription By RNA Polymerase II Protein O-linked Glycosylation Apoptotic Process Signal Transduction Response To Nutrient Viral Process Protein Processing Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Rac Protein Signal Transduction Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Histone H3-K27 Methylation Histone H3-K4 Trimethylation Positive Regulation Of Cold-induced Thermogenesis	Mitotic Sister Chromatid Segregation Osteoblast Differentiation DNA Replication-independent Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Gastrulation Anatomical Structure Morphogenesis Chromatin Silencing At Centromere Regulation Of Chromatin Silencing Muscle Cell Differentiation
Pathways		HATs acetylate histones UCH proteinases	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS			Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		22 interacting genes: CSNK2A1 CSNK2B GSK3B HCFC1 HIRA MAPT MTDH NUP62 NUP62CL OGA PHC3 PSG1 SIN3A SNAP91 SP1 SRF TAB1 TAB3 TRAK1 TRAK2 UBC YES1	14 interacting genes: ASF1A CCNA2 CDK2 H2BC12 H2BC21 H2BC5 H3-3B HIRIP3 HNRNPD NFU1 OGT PAX7 UBE2I UPF1
Entrez ID		8473	7290
HPRD ID		02222	02583
Ensembl ID		ENSG00000147162	ENSG00000100084
Uniprot IDs		O15294	P54198
PDB IDs		1W3B 3PE3 3PE4 3TAX 4AY5 4AY6 4CDR 4GYW 4GYY 4GZ3 4GZ5 4GZ6 4N39 4N3A 4N3B 4N3C 4XI9 4XIF 5BNW 5C1D 5HGV 5LVV 5LWV 5NPR 5NPS 5VIE 5VIF 6E37 6EOU 6IBO 6MA1 6MA2 6MA3 6MA4 6MA5	2I32 5YJE
Enriched GO Terms of Interacting Partners?
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