GTPBP3 and GNE

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GTPBP3	GNE
Description		GTP binding protein 3, mitochondrial	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion	Cytoplasm Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding
	Biological Process	TRNA Wobble Uridine Modification TRNA Methylation Embryonic Organ Development	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Cell Adhesion Carbohydrate Phosphorylation
Pathways		tRNA modification in the mitochondrion	Sialic acid metabolism Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2
Drugs
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nonaka distal myopathy (NM); Distal myopathy with rimmed vacuoles (DMRV); Hereditary inclusion body myopathy (hIBM) Sialuria/ Sialic acid storage disease, including: Infantile sialic acid storage disease (ISSD); Sialuria, Finnish type / Salla disease (SD); Sialuria, French type
GWAS		Mitochondrial DNA copy number ( 30704525)	Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)
Interacting Genes		9 interacting genes: CIC DCAF8 GNE PARP11 PFKL PRPF3 PTAFR RIBC2 SINHCAF	18 interacting genes: ADAMTSL4 CRMP1 GTPBP3 KIAA1549 KRT31 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP5-9 KRTAP9-2 NOTCH2NLA RIF1 SIGMAR1 SPRY2 ZBTB16
Entrez ID		84705	10020
HPRD ID		12255	04825
Ensembl ID		ENSG00000130299	ENSG00000159921
Uniprot IDs		B7Z563 Q969Y2	Q9Y223
PDB IDs			2YHW 2YHY 2YI1 3EO3 4ZHT
Enriched GO Terms of Interacting Partners?
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