GNE and KIAA1549

Number of citations of the paper that reports this interaction (PubMedID 17118363)
11

Data Source:
HPRD (two hybrid)

		GNE	KIAA1549
Description		glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	KIAA1549
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Protein Binding ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding
	Biological Process	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Cell Adhesion Carbohydrate Phosphorylation
Pathways		Sialic acid metabolism Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2	Signaling by BRAF and RAF fusions
Drugs
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nonaka distal myopathy (NM); Distal myopathy with rimmed vacuoles (DMRV); Hereditary inclusion body myopathy (hIBM) Sialuria/ Sialic acid storage disease, including: Infantile sialic acid storage disease (ISSD); Sialuria, Finnish type / Salla disease (SD); Sialuria, French type
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)	Heel bone mineral density ( 30598549)
Interacting Genes		18 interacting genes: ADAMTSL4 CRMP1 GTPBP3 KIAA1549 KRT31 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP5-9 KRTAP9-2 NOTCH2NLA RIF1 SIGMAR1 SPRY2 ZBTB16	10 interacting genes: CADPS CDC73 DST GNE ITSN2 LGALS4 MBD5 MYO5B SOD2 ZBTB16
Entrez ID		10020	57670
HPRD ID		04825	13873
Ensembl ID		ENSG00000159921	ENSG00000122778
Uniprot IDs		Q9Y223	Q9HCM3
PDB IDs		2YHW 2YHY 2YI1 3EO3 4ZHT
Enriched GO Terms of Interacting Partners?
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