CPSF1 and TAF12

Number of citations of the paper that reports this interaction (PubMedID 9311784)
120

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CPSF1	TAF12
Description		cleavage and polyadenylation specific factor 1	TATA-box binding protein associated factor 12
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GO Annotations	Cellular Component	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex STAGA Complex Transcription Factor TFTC Complex SLIK (SAGA-like) Complex
	Molecular Function	Protein Binding Enzyme Binding MRNA 3'-UTR AU-rich Region Binding	DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Heterodimerization Activity
	Biological Process	MRNA Splicing, Via Spliceosome Termination Of RNA Polymerase II Transcription MRNA Polyadenylation TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Export From Nucleus MRNA 3'-end Processing Pre-mRNA Cleavage Required For Polyadenylation	DNA-templated Transcription, Initiation Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Histone H3 Acetylation Positive Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II Preinitiation Complex Assembly Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript tRNA processing in the nucleus mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome HATs acetylate histones RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS		Educational attainment ( 25201988)	Type 2 diabetes ( 31049640)
Interacting Genes		16 interacting genes: CSTF2T CSTF3 GLIS2 HMOX1 IL7R MCM2 NEDD4 PAPOLA POLR2A PRRC2A REL TAF11 TAF12 TAF13 TAF5 TAF7	23 interacting genes: ATF7 CPSF1 H3-4 MYC NFYA NFYB NFYC PRKAR2B TAF1 TAF10 TAF11 TAF15 TAF1A TAF2 TAF4 TAF4B TAF5 TAF6 TAF7 TAF8 TAF9 TBP UBE2I
Entrez ID		29894	6883
HPRD ID		05823	15981
Ensembl ID		ENSG00000071894	ENSG00000120656
Uniprot IDs		Q10570	Q16514
PDB IDs		6BLY 6BM0 6DNH 6F9N 6FBS 6FUW 6URG 6URO	1H3O 6MZC 6MZD 6MZL 6MZM
Enriched GO Terms of Interacting Partners?
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