LZTS2 and DCUN1D1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LZTS2	DCUN1D1
Description		leucine zipper tumor suppressor 2	defective in cullin neddylation 1 domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol Microtubule Plasma Membrane Midbody Vesicle	Ubiquitin Ligase Complex Nucleoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding
	Biological Process	Mitotic Cytokinesis Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Microtubule Severing Nuclear Export Spindle Midzone Assembly Primary Ureteric Bud Growth Ureter Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus	Post-translational Protein Modification Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Neddylation
Pathways			Neddylation
Drugs
Diseases
GWAS		Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Regular attendance at a pub or social club ( 29970889)	Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)
Interacting Genes		176 interacting genes: ABT1 AEN ANKRD11 ANKRD36BP1 AP1M1 ARHGAP32 ARMC7 ARNT2 ATPAF2 BAHD1 BEX2 BMS1P1 BYSL C1orf109 C8orf33 CARD9 CBX8 CCDC198 CCDC85B CCNC CCNG1 CCNK CDC23 CDK18 CDKL3 CEP57L1 CFAP206 CHCHD3 CLIP4 CNNM3 COPB1 CWF19L2 DCUN1D1 DGCR6 DGCR6L DYRK2 EHHADH EIF3D EIF4E2 FAM107A FAM124B FAM161A FAM74A4 FANCL FEM1C FGF12 FKBP6 FNDC11 FRG1 FRMD6 GATA1 GCC1 GEM GFI1B GLIDR GMCL2 GNL3L GPANK1 GPATCH2L GRB2 HLA-DPB1 HM13 HOMER2 HOXB9 HSPD1 IQCE IQCN KAT5 KAZN KIF9 KIFC3 KPNA2 LASP1 LCK LIN37 LMO1 LMO2 MAB21L3 MAGEB4 MEMO1 MORF4L1 MORF4L2 MORN3 MOS MTA1 NCBP2 NCK2 NDE1 NEBL NEK6 NINL NIP7 NTAQ1 OTUB2 PAK5 PITX1 PKP4 PLEKHN1 POLDIP3 POLR1C PPP1R16A PPP1R18 PQBP1 PRKAB2 PRPF31 PSMA1 QARS1 RAC1 RAD51D RAMAC RBFOX1 RBM15 RBM41 RBPMS RCOR3 RHNO1 RHOXF2 RIN1 RNF32 RNF41 RTP5 RUNX1T1 SCNM1 SH2D4A SH3RF2 SHFL SLC15A3 SLC25A6 SLU7 SMARCB1 SMIM3 SNHG11 SNW1 SNX31 SPATA2 SPATA24 SPATC1L SPG7 SRSF2 STAC SUPV3L1 SUV39H1 TBC1D7 TCEA2 TCHP TEAD4 THAP10 THAP7 TNIP3 TRAF2 TRIM29 TRIM42 TSNAX TTC23 TXNL4A USF2 USP2 UTP14C WT1-AS YTHDC1 ZBTB25 ZBTB38 ZGPAT ZKSCAN3 ZMAT1 ZMAT2 ZMYND19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF446 ZNF490 ZNF512B ZNF572 ZNF581	25 interacting genes: ARIH1 ARIH2 ARRDC3 AURKB CALM1 CAND1 CUL5 DAZAP2 DVL2 LAPTM5 LZTS2 MAP3K1 NEDD4 RHOA RNF11 SMAD2 TLE5 TP53BP2 TRIM39 TRIM54 UBC UBE2D3 UBE2F UBE2M VPS37B
Entrez ID		84445	54165
HPRD ID		14341	12067
Ensembl ID		ENSG00000107816	ENSG00000043093
Uniprot IDs		B4DP66 Q9BRK4	B4DM76 C9JVE2 Q96GG9
PDB IDs			3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W
Enriched GO Terms of Interacting Partners?
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