DCUN1D1 and TRIM54

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DCUN1D1	TRIM54
Description		defective in cullin neddylation 1 domain containing 1	tripartite motif containing 54
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytosol	Microtubule Microtubule Associated Complex Z Disc
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin-like Protein Binding Cullin Family Protein Binding	Protein Binding Microtubule Binding Zinc Ion Binding
	Biological Process	Post-translational Protein Modification Protein Neddylation Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Neddylation	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Multicellular Organism Development Cell Differentiation
Pathways		Neddylation
Drugs
Diseases
GWAS		Parkinson's disease ( 27182965 28011712) Subjective response to lithium treatment ( 26503763)
Interacting Genes		25 interacting genes: ARIH1 ARIH2 ARRDC3 AURKB CALM1 CAND1 CUL5 DAZAP2 DVL2 LAPTM5 LZTS2 MAP3K1 NEDD4 RHOA RNF11 SMAD2 TLE5 TP53BP2 TRIM39 TRIM54 UBC UBE2D3 UBE2F UBE2M VPS37B	132 interacting genes: ADCY4 ARFIP2 ARHGEF5 ATXN3 ATXN3L ATXN7 BYSL C12orf49 C1orf109 C1orf216 C1QTNF2 C2CD6 CALM3 CARD9 CCDC102B CCDC146 CCDC28A CCDC87 CDK18 CDKN1A CENPX CEP57L1 CHCHD2 CKM CRADD CWF19L2 CYTH4 DCUN1D1 DEUP1 DNAL4 DTX2 EHHADH EIF4E2 ELMO1 ELOA ENKD1 EPM2AIP1 EXOSC5 FAM110A FAM124A FAM124B FAM161A FARS2 FBF1 FLNC GEM GMCL1 GTF2IRD2 HAUS1 HSPB1 ING3 INPP5J IQUB JOSD1 KDM1A KIFC3 KLHL38 KPNA2 KRT6A KRT6B KRT6C LENG1 LIN37 LMO2 LNX1 LSM2 MAPK3 MBD3 MCM7 MEAF6 MFAP1 MID2 MYO5B NGLY1 NTAQ1 OSTF1 OTUB1 OTUB2 PIK3R3 PPP1R18 PRF1 RABGEF1 RAD23A RBM41 RCOR3 RSRC2 SCNM1 SDCBP SENP3 SH2D1B SMARCE1 SNF8 SPG21 SSX2IP STAM TBC1D22B TCEA2 THOC1 TRIM55 TRIM63 TSHZ3 TTC23 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP4 USP5 USP7 USP8 UTP14C VPS28 WDR34 YOD1 ZBTB16 ZGPAT ZNF250 ZNF417 ZNF572 ZNF587
Entrez ID		54165	57159
HPRD ID		12067	05928
Ensembl ID		ENSG00000043093	ENSG00000138100
Uniprot IDs		B4DM76 C9JVE2 Q96GG9	Q9BYV2
PDB IDs		3TDU 3TDZ 4P5O 5UFI 5V83 5V86 5V88 6B5Q 6BG3 6BG5 6P5V 6P5W	3Q1D
Enriched GO Terms of Interacting Partners?
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