MAML2 and DIABLO

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MAML2	DIABLO
Description		mastermind like transcriptional coactivator 2	diablo IAP-binding mitochondrial protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Mitochondrion Mitochondrial Intermembrane Space Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Transcription Coactivator Activity	Protein Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Positive Regulation Of Apoptotic Process Neuron Apoptotic Process Intrinsic Apoptotic Signaling Pathway
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	Release of apoptotic factors from the mitochondria SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Regulation of the apoptosome activity
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal astigmatism ( 23322567) Height ( 23456168) Influenza A (H1N1) severity ( 26379185) Keratoconus ( 31855235) Methadone dose in opioid dependence ( 28115739) Non-glioblastoma glioma ( 28346443) Pelvic organ prolapse ( 26545240) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Response to treatment for acute lymphoblastic leukemia ( 19176441) Ulcerative colitis ( 28067908 23128233) Waist-to-hip circumference ratio (alcohol intake interaction) ( 23192594)
Interacting Genes		7 interacting genes: CREBBP CTBP1 DIABLO NOTCH1 NOTCH2 NOTCH3 NOTCH4	23 interacting genes: AGTRAP AREL1 ARL6IP1 ARNT BEX3 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP9 E2F1 EEF1A1 HTRA2 LTBR MAML2 NR4A1 SBNO1 SLC25A47 UBE2K UFM1 XIAP ZNF746
Entrez ID		84441	56616
HPRD ID		09608	05560
Ensembl ID		ENSG00000184384	ENSG00000184047
Uniprot IDs		Q8IZL2	A0A024RBT2 A0A0S2Z5P6 A0A0S2Z5U7 K7X1S0 Q502X2 Q9NR28
PDB IDs			1FEW 1G3F 1G73 1OXQ 1TW6 1XB0 1XB1 3D9U 3UIH 3UIJ 4TX5
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?