MAML2 and NOTCH4

Number of citations of the paper that reports this interaction (PubMedID 12370315)
71

Data Source:
HPRD (in vivo)

		MAML2	NOTCH4
Description		mastermind like transcriptional coactivator 2	notch receptor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Transcription Coactivator Activity	Notch Binding Calcium Ion Binding Protein Binding Signaling Receptor Activity
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II	Branching Involved In Blood Vessel Morphogenesis Cell Fate Determination Morphogenesis Of A Branching Structure Endothelial Cell Morphogenesis Vasculature Development Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription Of Notch Receptor Target Hemopoiesis Cell Differentiation Mammary Gland Development MiRNA Mediated Inhibition Of Translation Wound Healing Negative Regulation Of Cell Differentiation Negative Regulation Of Endothelial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Negative regulation of NOTCH4 signaling
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal astigmatism ( 23322567) Height ( 23456168) Influenza A (H1N1) severity ( 26379185) Keratoconus ( 31855235) Methadone dose in opioid dependence ( 28115739) Non-glioblastoma glioma ( 28346443) Pelvic organ prolapse ( 26545240) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Response to treatment for acute lymphoblastic leukemia ( 19176441) Ulcerative colitis ( 28067908 23128233) Waist-to-hip circumference ratio (alcohol intake interaction) ( 23192594)	Advanced glycation end-product levels ( 26083729) Age-related macular degeneration ( 22694956) Aspartate aminotransferase levels ( 29403010) Asthma ( 21804548 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Blood protein levels in cardiovascular risk ( 28369058) Chronic hepatitis B infection ( 25802187) Circulating myeloperoxidase levels (serum) ( 23620142) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 26876947) Colorectal cancer ( 30529582) Crohn's disease ( 23266558) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Food antigen IgG levels ( 24962563) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Iron status biomarkers (iron levels) ( 28334935) Joint mobility (Beighton score) ( 27182965) Longevity ( 30294719) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Lupus nephritis in systemic lupus erythematosus ( 24925725) Migraine ( 27322543) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Obesity-related traits ( 23251661) Objective response to lithium treatment in bipolar disorder ( 26503763) Prostate cancer ( 23535732) Reticulocyte fraction of red cells ( 27863252) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 19571808 30285260 23894747) Squamous cell lung carcinoma ( 28604730) Systemic lupus erythematosus ( 21408207) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 24837172 28067908) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		7 interacting genes: CREBBP CTBP1 DIABLO NOTCH1 NOTCH2 NOTCH3 NOTCH4	14 interacting genes: DLL4 EGFL7 ELOC FBXW7 MAML1 MAML2 MAML3 NEU1 PSEN1 PSEN2 RBPJ SMAD2 SMAD3 SMAD4
Entrez ID		84441	4855
HPRD ID		09608	01290
Ensembl ID		ENSG00000184384	ENSG00000204301
Uniprot IDs		Q8IZL2	A0A1U9X983 Q99466
PDB IDs
Enriched GO Terms of Interacting Partners?
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