CASP10 and CASP4

Number of citations of the paper that reports this interaction (PubMedID 8962078)
77

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		CASP10	CASP4
Description		caspase 10	caspase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex IPAF Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Cysteine-type Endopeptidase Activity Protein Binding CARD Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Signaling Pathway	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Innate Immune Response Regulation Of Inflammatory Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	NOD1/2 Signaling Pathway
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 28165464 23770605) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831)	Major depressive disorder ( 29317602)
Interacting Genes		32 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 NPTX1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP SCARB1 TNFRSF1A TRAF1 XIAP	16 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9
Entrez ID		843	837
HPRD ID		03458	04047
Ensembl ID		ENSG00000003400	ENSG00000196954
Uniprot IDs		A0A0S2Z3G5 A0A0S2Z3Z5 Q92851	P49662
PDB IDs
Enriched GO Terms of Interacting Partners?
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