CASP4 and DSP

Number of citations of the paper that reports this interaction (PubMedID 15500642)
8

Data Source:
HPRD (in vitro)

		CASP4	DSP
Description		caspase 4	desmoplakin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex IPAF Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex	Cornified Envelope Nucleus Cytoplasm Intermediate Filament Plasma Membrane Fascia Adherens Intercalated Disc Membrane Basolateral Plasma Membrane Cell Junction Desmosome Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding CARD Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	RNA Binding Protein Kinase C Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cell Adhesion Molecule Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Scaffold Protein Binding
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Innate Immune Response Regulation Of Inflammatory Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta	Desmosome Organization Ventricular Compact Myocardium Morphogenesis Epidermis Development Peptide Cross-linking Keratinocyte Differentiation Keratinization Adherens Junction Organization Wound Healing Neutrophil Degranulation Skin Development Intermediate Filament Cytoskeleton Organization Intermediate Filament Organization Cornification Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Regulation Of Heart Rate By Cardiac Conduction Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		NOD1/2 Signaling Pathway	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs			Zinc Artenimol
Diseases			Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome Striate palmoplantar keratoderma Skin fragility-woolly hair syndrome Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Major depressive disorder ( 29317602)	Chronic obstructive pulmonary disease ( 28166215 30804561) Idiopathic pulmonary fibrosis ( 29066090) Interstitial lung disease ( 23583980) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Numerical cognitive ability ( 31620175) Response to fenofibrate (triglyceride levels) ( 27002377) Resting heart rate ( 27798624)
Interacting Genes		16 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9	30 interacting genes: ARID3A CASP10 CASP2 CASP4 CASP6 CASP7 CASP9 CDH5 COL17A1 CSTA DES DSC1 EVPL GRPEL1 IVL JUP KRT1 KRT5 KRT6A MTDH PECAM1 PKP1 PKP2 PKP3 PKP4 PRKACA PRKCE PTEN UCHL5 VIM
Entrez ID		837	1832
HPRD ID		04047	00513
Ensembl ID		ENSG00000196954	ENSG00000096696
Uniprot IDs		P49662	B4DKX6 P15924 Q4LE79
PDB IDs			1LM5 1LM7 3R6N 5DZZ
Enriched GO Terms of Interacting Partners?
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