CASP10 and OIP5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CASP10	OIP5
Description		caspase 10	Opa interacting protein 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromocenter Cajal Body Nuclear Speck Intracellular Membrane-bounded Organelle
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Signaling Pathway	Cell Cycle Chromosome Segregation Cell Communication CENP-A Containing Nucleosome Assembly Cell Division
Pathways		TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 28165464 23770605) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Ulcerative colitis ( 28067908)
Interacting Genes		32 interacting genes: BFAR BID CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 FADD NFKBIL1 NPTX1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP SCARB1 TNFRSF1A TRAF1 XIAP	22 interacting genes: ABL2 BRAF C1orf94 CASP10 CEP170P1 EIF4ENIF1 FOXJ1 GCC1 HJURP KDM1A KRT15 NUP62 PEX19 RAF1 RARG SKIL TFIP11 TMPO TPM3 TRIP6 TSSK3 VPS39
Entrez ID		843	11339
HPRD ID		03458	09352
Ensembl ID		ENSG00000003400	ENSG00000104147
Uniprot IDs		A0A0S2Z3G5 A0A0S2Z3Z5 Q92851	A0A024R9N0 O43482
PDB IDs
Enriched GO Terms of Interacting Partners?
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