OIP5 and ABL2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		OIP5	ABL2
Description		Opa interacting protein 5	ABL proto-oncogene 2, non-receptor tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Nucleus Nucleoplasm Chromocenter Cajal Body Nuclear Speck Intracellular Membrane-bounded Organelle	Cell Cytosol Actin Cytoskeleton
	Molecular Function	Protein Binding Identical Protein Binding Metal Ion Binding	Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding
	Biological Process	Cell Cycle Chromosome Segregation Cell Communication CENP-A Containing Nucleosome Assembly Cell Division	Cellular Protein Modification Process Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Regulation Of Apoptotic Process Positive Regulation Of Oxidoreductase Activity Cellular Response To Retinoic Acid Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization
Pathways		Deposition of new CENPA-containing nucleosomes at the centromere	Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling
Drugs			ATP Dasatinib XL228 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Ulcerative colitis ( 28067908)	IgE grass sensitization ( 22036096)
Interacting Genes		22 interacting genes: ABL2 BRAF C1orf94 CASP10 CEP170P1 EIF4ENIF1 FOXJ1 GCC1 HJURP KDM1A KRT15 NUP62 PEX19 RAF1 RARG SKIL TFIP11 TMPO TPM3 TRIP6 TSSK3 VPS39	29 interacting genes: ABL1 BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK MAP3K10 MDM2 NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10
Entrez ID		11339	27
HPRD ID		09352	01259
Ensembl ID		ENSG00000104147	ENSG00000143322
Uniprot IDs		A0A024R9N0 O43482	P42684
PDB IDs			2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5
Enriched GO Terms of Interacting Partners?
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