WDR83 and EGLN3

Number of citations of the paper that reports this interaction (PubMedID 16407229)
18

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		WDR83	EGLN3
Description		WD repeat domain 83	egl-9 family hypoxia inducible factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Spliceosomal Complex Endosome Membrane Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity
	Biological Process	MAPK Cascade RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome Response To Hypoxia	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways		MAP2K and MAPK activation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Vitamin C Roxadustat
Diseases
GWAS			Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252)
Interacting Genes		17 interacting genes: BAG2 CRB3 CRK EGLN3 GPKOW HNRNPH2 HSPB1 KDM1A KEAP1 LSM3 PARD6A PARD6B PCBP2 RACK1 SAP30BP SF1 TOE1	25 interacting genes: ABI2 ADRB2 ATF4 EFHC2 EPAS1 EPOR FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK7 NCAPH2 OS9 PKM PRPF19 SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83
Entrez ID		84292	112399
HPRD ID		14730	06972
Ensembl ID		ENSG00000123154	ENSG00000129521
Uniprot IDs		Q9BRX9	B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9
PDB IDs
Enriched GO Terms of Interacting Partners?
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