USP48 and GLI1

Number of citations of the paper that reports this interaction (PubMedID 28623188)
9

Data Source:
BioGRID (enzymatic study)

		USP48	GLI1
Description		ubiquitin specific peptidase 48	GLI family zinc finger 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Axoneme Ciliary Tip Ciliary Base
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Microtubule Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination	Osteoblast Differentiation Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Proliferation Regulation Of Smoothened Signaling Pathway Response To Wounding Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Prostate Gland Development Regulation Of Osteoblast Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Morphogenesis Notochord Regression Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Liver Regeneration Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Hepatocyte Proliferation
Pathways		Ub-specific processing proteases	Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Type 2 diabetes ( 30718926)
Interacting Genes		5 interacting genes: APP CSNK2A1 DRD3 GLI1 UBC	18 interacting genes: CRYBA4 DYRK1A FEM1B GCC1 IKBKB PRKAA2 PRKACA PRMT5 RAI1 STK36 SUFU TAF9 TRIM42 USP48 WDR77 XBP1 ZIC1 ZIC2
Entrez ID		84196	2735
HPRD ID		15637	01311
Ensembl ID		ENSG00000090686	ENSG00000111087
Uniprot IDs		Q86UV5	B4DNF7 P08151
PDB IDs			2GLI 4BLB 4KMD 5OM0
Enriched GO Terms of Interacting Partners?
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